For each frame of animation we need to update the VBO. In games we can run. And we can run and shot in same time. How games are combine the animations?
Do you have a skeletal animation system in-place? What’s often done here is called animation track blending. For some good intro reading, check out Chapter 11 of Jason Gregory’s Game Engine Architecture. Particularly the Animation Blending and Action State Machines sections. There’s also software out there you can buy to help you and your artists generate these blends and drive them from the application.